Article
Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4.
British journal of cancer - 1 Feb 2022
Ouahoud Sarah, Jacobs Rutger J, Kodach Ludmilla L, Voorneveld Philip W, Hawinkels Lukas J A C, Weil Nikki L, van Vliet Britt, Herings Ron M, van der Burg Lennart R A, van Wezel Tom, Morreau Hans, Slingerland Marije, Bastiaannet Esther, Putter Hein, Hardwick James C H
Abstract excerpt
BACKGROUND: Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to act on KRAS, we have previously proposed that they act via influencing the BMP pathway. The objective of this study was to look for associations between statin use and the risk of developing colorectal cancer of a particular...
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