Article
Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women.
Genes, chromosomes & cancer - 1 Nov 2011
Passarelli Michael N, Coghill Anna E, Hutter Carolyn M, Zheng Yingye, Makar Karen W, Potter John D, Newcomb Polly A
Abstract excerpt
Common single nucleotide polymorphisms (SNPs) in SMAD7 (18q21) have been linked to colorectal cancer (CRC) risk in genome-wide association studies, but little is known about their effects on survival. SMAD7 regulates gastrointestinal inflammation by inhibiting transforming growth factor-β (TGFB), which can act as both a tumor suppressor and a promoter of metastasis. Regular use of cyclooxygenase-2 (COX2)...
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