Article
Single-Nucleotide Polymorphisms of the MSH2 and MLH1 Genes, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population.
Pathology oncology research : POR - 1 Jul 2018
da Silva Calixto Poliane, Lopes Otávio Sérgio, Dos Santos Maia Mayara, Herrero Sylvia Satomi Takeno, Longui Carlos Alberto, Melo Cynthia Germoglio Farias, de Carvalho Filho Ivan Rodrigues, Soares Leonardo Ferreira, de Medeiros Arnaldo Correia, Delatorre Plínio, Khayat André Salim, Burbano Rommel Rodriguez, Lima Eleonidas Moura
Abstract excerpt
Basal cell carcinoma - BCC is considered a multifactorial neoplasm involving genetic, epigenetic and environmental factors. Where UVB radiation is considered the main physical agent involved in BCC carcinogenesis. The Brazil and state of Paraíba are exposed to high levels of UVB rays. The mismatch repair - MMR is important DNA repair mechanisms to maintain replication fidelity. Therefore, single nucleotide...
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