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Article

Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility.

JCI insight - 9 Aug 2018

Cho Hyunje G, Kuo Karen Y, Li Shufeng, Bailey Irene, Aasi Sumaira, Chang Anne Lynn S, Oro Anthony E, Tang Jean Y, Sarin Kavita Y

Abstract excerpt

Innate DNA repair mechanisms play a critical role in protecting skin keratinocytes from UV mutagenesis and skin cancer development. We hypothesized that individuals who develop frequent skin cancers may harbor germline defects in DNA repair genes and have increased predisposition to internal malignancies. We enrolled 61 patients with unusually frequent basal cell carcinoma (BCC) development, seen at Stanford...

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Topics

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Share to Carcinogenesis
Share to Carcinoma, Basal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30089731
DOI: 10.1172/jci.insight.122744
PMCID: PMC6129130

Genes

APC
BARD1
BRCA1
BRCA2
CDH1
CHEK2
MLH1
MSH2
MSH6
MUTYH
NBN
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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