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Article

Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2016

Mukohda Masashi, Stump Madeliene, Ketsawatsomkron Pimonrat, Hu Chunyan, Quelle Frederick W, Sigmund Curt D

Abstract excerpt

Loss of peroxisome proliferator-activated receptor (PPAR)-γ function in the vascular endothelium enhances atherosclerosis and NF-κB target gene expression in high-fat diet-fed apolipoprotein E-deficient mice. The mechanisms by which endothelial PPAR-γ regulates inflammatory responses and protects against atherosclerosis remain unclear. To assess functional interactions between PPAR-γ and inflammation, we used a...

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Identifiers

PMID: 26566726
DOI: 10.1152/ajpheart.00490.2015
PMCID: PMC4796462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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