Article
Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.
Alimentary pharmacology & therapeutics - 1 Jan 2018
Lang B M, Biedermann L, van Haaften W T, de Vallière C, Schuurmans M, Begré S, Zeitz J, Scharl M, Turina M, Greuter T, Schreiner P, Heinrich H, Kuntzen T, Vavricka S R, Rogler G, Beerenwinkel N, Misselwitz B
Abstract excerpt
BACKGROUND: Smoking is a strong environmental factor leading to adverse outcomes in Crohn's disease, but a more benign course in ulcerative colitis. Several single nucleotide polymorphisms (SNPs) are associated with smoking quantity and behaviour. AIM: To assess whether smoking-associated SNPs interact with smoking to influence the clinical course of inflammatory bowel diseases. METHODS: Genetic and prospectively...
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