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Article

A case-only study of gene-environment interaction between genetic susceptibility variants in NOD2 and cigarette smoking in Crohn's disease aetiology.

BMC medical genetics - 14 Mar 2012

Helbig Katherine L, Nothnagel Michael, Hampe Jochen, Balschun Tobias, Nikolaus Susanna, Schreiber Stefan, Franke Andre, Nöthlings Ute

Abstract excerpt

BACKGROUND: Genetic variation in NOD2 and cigarette smoking are well-established risk factors for the development of Crohn's disease (CD). However, little is known about a potential interaction between these risk factors. We investigated gene-environment interactions between CD-associated NOD2 alleles and cigarette smoking in a large sample of patients with CD. METHODS: Three previously reported CD-associated...

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Source

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Identifiers

PMID: 22416979
DOI: 10.1186/1471-2350-13-14
PMCID: PMC3314543

Genes

NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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