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Article

Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.

Nature communications - 15 May 2017

Arasaki Kohei, Mikami Yumi, Shames Stephanie R, Inoue Hiroki, Wakana Yuichi, Tagaya Mitsuo

Abstract excerpt

During infection of macrophages, the pathogenic bacterium Legionella pneumophila secretes effector proteins that induce the conversion of the plasma membrane-derived vacuole into an endoplasmic reticulum (ER)-like replicative vacuole. These ER-like vacuoles are ultimately fused with the ER, where the pathogen replicates. Here we show that the L. pneumophila effector Lpg1137 is a serine protease that targets the...

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Identifiers

PMID: 28504273
DOI: 10.1038/ncomms15406
PMCID: PMC5440676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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