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Article

Legionella suppresses the host unfolded protein response via multiple mechanisms

29 Jul 2015

Abstract excerpt

The intracellular pathogen, Legionella pneumophila, secretes ∼300 effector proteins to modulate the host environment. Given the intimate interaction between L. pneumophila and the endoplasmic reticulum, we investigated the role of the host unfolded protein response (UPR) during L. pneumophila infection. Interestingly, we show that the host identifies L. pneumophila infection as a form of endoplasmic reticulum...

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PMID: 26219498
DOI: 10.1038/ncomms8887

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