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Article

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

3 May 2019

Abstract excerpt

Mitophagy is the selective autophagic targeting and removal of dysfunctional mitochondria. While PINK1/Parkin-dependent mitophagy is well-characterized, PINK1/Parkin-independent route is poorly understood. Using structure illumination microscopy (SR-SIM), we demonstrate that the SNARE protein Syntaxin 17 (STX17) initiates mitophagy upon depletion of outer mitochondrial membrane protein Fis1. With proteomics...

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PMID: 31053718
DOI: 10.1038/s41467-019-10096-1

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