Article
TypeLoader: A fast and efficient automated workflow for the annotation and submission of novel full-length HLA alleles.
HLA - 1 Jul 2017
Surendranath V, Albrecht V, Hayhurst J D, Schöne B, Robinson J, Marsh S G E, Schmidt A H, Lange V
Abstract excerpt
Recent years have seen a rapid increase in the discovery of novel allelic variants of the human leukocyte antigen (HLA) genes. Commonly, only the exons encoding the peptide binding domains of novel HLA alleles are submitted. As a result, the IPD-IMGT/HLA Database lacks sequence information outside those regions for the majority of known alleles. This has implications for the application of the new sequencing...
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