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Article

Clinically significant sub-clonality for common drivers can be detected in 26% of KRAS/EGFR mutated lung adenocarcinomas.

Oncotarget - 11 Jul 2017

Simon Einav, Bick Tova, Sarji Shada, Shentzer Talia, Prinz Elad, Yehiam Liza, Sabo Edmond, Ben-Izhak Ofer, Hershkovitz Dov

Abstract excerpt

Genetic sub-clonality has been described in multiple malignancies, however the presence of sub-clonality for major drivers in lung adenocarcinoma and its clinical significance is a subject under debate. Using molecular and morphometric approach, 347 lung adenocarcinoma samples were analyzed for KRAS and EGFR sub-clonality, which was further correlated with clinical and pathological variables.KRAS and EGFR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28501852
DOI: 10.18632/oncotarget.17399
PMCID: PMC5542222

Genes

EGFR
KRAS

Provenance

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