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Article

Clonal Origin Evaluated by Trunk and Branching Drivers and Prevalence of Mutations in Multiple Lung Tumor Nodules.

Molecular diagnosis & therapy - 1 Aug 2020

Rodriguez Erika F, Tseng Li-Hui, De Marchi Federico, Haung Jialing, Belchis Deborah, Xian Rena, Gocke Christopher D, Eshleman James R, Illei Peter B, Lin Ming-Tseh

Abstract excerpt

INTRODUCTION: Differentiation between intrapulmonary metastasis (IPM) and multiple primary lung cancers (MPLC) in patients with synchronous or metachronous lung tumor nodules is critical but challenging. OBJECTIVE: We proposed an algorithm to evaluate clonal origin based on trunk (initiating) versus branching drivers and the prevalence of mutations in lung adenocarcinomas. METHODS: Driver mutations were examined...

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PMID: 32504414
DOI: 10.1007/s40291-020-00471-w

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