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Article

Coexisting driver alterations in non-small cell lung cancer: Prevalence, clonal architecture, and impact on survival and progression.

European journal of cancer (Oxford, England : 1990) - 9 Sept 2026

Shah Rashmi, Pathak Gopal P, Fris John, Castonguay Mathieu, Gillan Tanya, Carter Michael D, Xu Zhaolin

Abstract excerpt

BACKGROUND: Coexisting driver mutations in non-small cell lung cancer (NSCLC) can influence tumor biology, therapeutic response, and patient outcomes, yet these implications remain underexplored. METHODS: 5420 NSCLC cases from QEII Health Sciences Centre were analyzed. Major driver variants were assessed, and clinical and survival data were analyzed. RESULTS: KRAS mutations were the most common variants, followed...

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Carcinoma, Non-Small-Cell Lung
Class I Phosphatidylinositol 3-Kinases
Disease Progression
ErbB Receptors
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-akt

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 42456541
DOI: 10.1016/j.ejca.2026.116936

Genes

KRAS
EGFR
PIK3CA
AKT1
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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