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Article

The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.

Arthritis and rheumatism - 1 Feb 2011

Rodríguez-Rodríguez Luis, Taib Wan Rohani Wan, Topless Ruth, Steer Sophia, González-Escribano María F, Balsa Alejandro, Pascual-Salcedo Dora, González-Gay Miguel A, Raya Enrique, Fernandez-Gutierrez Benjamín, González-Álvaro Isidoro, Bottini Nunzio, Witte Torsten, Viken Marte K, Coenen Marieke J H, van Riel Piet L C M, Franke Barbara, den Heijer Martin, Radstake Timothy R D J, Wordsworth Paul, Lie Benedicte A, Merriman Tony R, Martín Javier

Abstract excerpt

OBJECTIVE: Recently, a functional PTPN22 variant (R263Q; rs33996649) was found to be associated with systemic lupus erythematosus (SLE). This study was undertaken to analyze the influence of this polymorphism on the risk of rheumatoid arthritis (RA). METHODS: RA patients (n = 5,579) were recruited from outpatient clinics from 6 different countries (Spain, New Zealand, the UK, Norway, The Netherlands, and...

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Source

Identifiers

PMID: 21279993
DOI: 10.1002/art.30145

Genes

PTPN22

Variants

rs33996649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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