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Manipulating the Mitochondrial Genome To Enhance Cattle Embryo Development

13 May 2017

Abstract excerpt

Abstract The mixing of mitochondrial DNA (mtDNA) from the donor cell and the recipient oocyte in embryos and offspring derived from somatic cell nuclear transfer (SCNT) compromises genetic integrity and affects embryo development. We set out to generate SCNT embryos that inherited their mtDNA from the recipient oocyte only, as is the case following natural conception. While SCNT blastocysts produced from Holstein...

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PMID: 28500053
DOI: 10.1534/g3.117.042655

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