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Reprogramming towards totipotency is greatly facilitated by synergistic effects of small molecules

15 Apr 2017

Abstract excerpt

Animal cloning has been achieved in many species by transplanting differentiated cell nuclei to unfertilized oocytes. However, the low efficiencies of cloning have remained an unresolved issue. Here we find that the combination of two small molecules, trichostatin A (TSA) and vitamin C (VC), under culture condition with bovine serum albumin deionized by ion-exchange resins, dramatically improves the cloning...

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PMID: 28412714
DOI: 10.1242/bio.023473

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