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Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning

31 Jan 2008

Abstract excerpt

The birth of 'Dolly', the first mammal cloned from an adult donor cell, has sparked a flurry of research activities to improve cloning technology and to understand the underlying mechanism of epigenetic reprogramming of the transferred somatic cell nucleus. Especially in ruminants, somatic cell nuclear transfer (SCNT) is frequently associated with pathological changes in the foetal and placental phenotype and has...

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PMID: 18239046
DOI: 10.1530/rep-07-0397

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