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Donor-host mitochondrial compatibility improves efficiency of bovine somatic cell nuclear transfer

19 Mar 2010

Abstract excerpt

BACKGROUND: The interaction between the karyoplast and cytoplast plays an important role in the efficiency of somatic cell nuclear transfer (SCNT), but the underlying mechanism remains unclear. It is generally accepted that in nuclear transfer embryos, the reprogramming of gene expression is induced by epigenetic mechanisms and does not involve modifications of DNA sequences. In cattle, oocytes with various...

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PMID: 20302653
DOI: 10.1186/1471-213x-10-31

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