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Article

PER2 is downregulated by the LPS-induced inflammatory response in synoviocytes in rheumatoid arthritis and is implicated in disease susceptibility.

Molecular medicine reports - 1 Jul 2017

Lee Hwayoung, Nah Seong-Su, Chang Sung-Hae, Kim Hyung-Ki, Kwon Jun-Tack, Lee Sanghyun, Cho Ik-Hyun, Lee Sang Won, Kim Young Ock, Hong Seung-Jae, Kim Hak-Jae

Abstract excerpt

The clinical symptoms of rheumatoid arthritis (RA) present with circadian variation, with joint stiffness and pain more prominent in the early morning. The mammalian clock genes, which include circadian locomotor output cycles kaput, brain and muscle Arnt-like protein 1, period and cryptochrome, regulate circadian rhythms. In order to identify the association between genetic polymorphisms in the circadian clock...

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Identifiers

PMID: 28498398
DOI: 10.3892/mmr.2017.6578

Genes

PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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