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Circadian regulators PER1 and PER2 regulate osteoclastogenesis by balancing competing activities of innate immunity genes

2026-01-11

Abstract excerpt

Bone remodeling is influenced by circadian rhythms as demonstrated by global gene expression patterns and the phenotypes of knockout mice of circadian regulators. However, the direct connections between circadian regulators and specific bone genes remain unclear. We previously found that a conditional knockout of Per1 , a central circadian regulator, in osteoclasts increased osteoclastogenesis and decreased bone...

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Literature Corpus work
24a1889d-fd50-5b0d-83b2-9366e6950798
DOI
10.64898/2026.01.11.698889
Open publication

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Circadian regulators PER1 and PER2 regulate osteoclastogenesis by balancing competing activities of innate immunity genesDOI 10.64898/2026.01.11.698889
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