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Methylation of DIRAS1 promotes colorectal cancer progression and may serve as a marker for poor prognosis

10 May 2017

Abstract excerpt

DIRAS1 is a new member of the Ras gene family. It was described as a potential tumor suppressor in human glioblastomas and esophageal cancer. The role of DIRAS1 in colorectal cancer remains unclear. To explore the epigenetic changes and function of DIRAS1 in human colorectal cancer, we studied ten colorectal cancer cell lines and 146 primary colorectal cancer samples and 50 matched adjacent samples using...

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PMID: 28491151
DOI: 10.1186/s13148-017-0348-0

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