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Article

Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression.

BioMed research international - 1 Jan 2013

Peng Haixia, Long Feng, Wu Zhiyuan, Chu Yimin, Li Ji, Kuai Rong, Zhang Jing, Kang Zhihua, Zhang Xinju, Guan Ming

Abstract excerpt

PURPOSE: DLC-1 is a tumor suppressor gene frequently silenced in human cancers. However, the pathogenicity of DLC-1 epigenetic silencing in the mucosa-adenoma-carcinoma transformation process of colorectal cancer (CRC) has not been studied. METHODS: Promoter methylation status of DLC-1 was evaluated in 4 human CRC cell lines, 48 normal mucosa, 57 adenomas, and 80 CRC tissues with methylation-sensitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 23509688
DOI: 10.1155/2013/181384
PMCID: PMC3591122

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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