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Article

p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line.

PloS one - 1 Jan 2014

Organ Shawna L, Hai Josephine, Radulovich Nikolina, Marshall Christopher B, Leung Lisa, Sasazuki Takehiko, Shirasawa Senji, Zhu Chang-Qi, Navab Roya, Ikura Mitsuhiko, Tsao Ming-Sound

Abstract excerpt

KRAS is mutated in ∼40% of colorectal cancer (CRC), and there are limited effective treatments for advanced KRAS mutant CRC. Therefore, it is crucial that downstream mediators of oncogenic KRAS continue to be studied. We identified p190RhoGAP as being phosphorylated in the DLD1 CRC cell line, which expresses a heterozygous KRAS G13D allele, and not in DKO4 in which the mutant allele has been deleted by somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24465899
DOI: 10.1371/journal.pone.0086103
PMCID: PMC3897622

Genes

KRAS

Variants

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