Article

Model-Dependent Renal Phenotypes in Diabetic Kidney Disease: Comparative Histopathological Characterization of Commonly Used Animal Models

2026-07-08

Abstract excerpt

<h4>Background</h4> Diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease worldwide, characterized by progressive structural and metabolic alterations secondary to chronic hyperglycemia. While numerous type 1 and type 2 rodent models have been developed to study the pathophysiology of DKD, no single model perfectly recapitulates the full clinical spectrum of human disease. The selection...

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Literature Corpus work: ea935509-c7ed-505f-816d-a59bb7238e23
DOI: 10.64898/2026.07.02.736132

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