Article
Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Apr 2010
Shiota Atsushi, Yamamoto Koichi, Ohishi Mitsuru, Tatara Yuji, Ohnishi Miyuki, Maekawa Yoshihiro, Iwamoto Yoshihiro, Takeda Masao, Rakugi Hiromi
Abstract excerpt
As angiotensin-converting enzyme-2 (ACE2) was identified as a negative regulator of the renin-angiotensin system, there have been many reports concerning its role in several tissues, including the kidney. However, the role of ACE2 during the development of diabetic nephropathy remains undetermined, as previous reports did not necessarily support a protective role against renal injury. Thus, we performed detailed...
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