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Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development

20 Aug 2015

Abstract excerpt

Notch pathway activation in podocytes has been shown to play an important role in diabetic kidney disease (DKD) development; however, the receptors and ligands involved in the process have not been identified. Here, we report that conditional deletion of Notch1 in podocytes using NPHS2(cre)Notch1(flox/flox) animals resulted in marked amelioration of DKD. On the contrary, podocyte-specific genetic deletion of...

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PMID: 26293507
DOI: 10.2337/db15-0260

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