Article
Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization.
Molecular and cellular endocrinology - 25 Apr 2002
Brothers Shaun P, Janovick Jo Ann, Maya-Nunez Guadalupe, Cornea Anda, Han Xin-Bing, Conn P Michael
Abstract excerpt
The mammalian gonadotropin-releasing hormone receptor (GnRHR), with 327 amino acids, is among the smallest G protein coupled receptors identified. Absent from this receptor is the cytoplasmic tail, characteristic of other members of this superfamily, which frequently mediates desensitization and down-regulation. The fifteen carboxyl terminal residues in the mammalian GnRHR are absolutely conserved, suggesting...
Topics
- Animals
- Binding Sites
- Cells, Cultured
- Endocytosis
- Ligands
- Microscopy, Confocal
- Molecular Sequence Data
- Mutation
- Protein Binding
- Rats
- Receptors, LHRH