Article
Functional dissection of protein domains involved in the immunomodulatory properties of PE_PGRS33 of Mycobacterium tuberculosis.
Pathogens and disease - 1 Dec 2013
Zumbo Antonella, Palucci Ivana, Cascioferro Alessandro, Sali Michela, Ventura Marcello, D'Alfonso Pamela, Iantomasi Raffaella, Di Sante Gabriele, Ria Francesco, Sanguinetti Maurizio, Fadda Giovanni, Manganelli Riccardo, Delogu Giovanni
Abstract excerpt
PE_PGRSs are a large family of proteins identified in Mycobacterium tuberculosis complex and in few other pathogenic mycobacteria. The PE domain of PE_PGRS33 mediates localization of the protein on the mycobacterial cell surface, where the PGRS domain is available to interact with host components. In this study, PE_PGRS33 and its functional deletion mutants were expressed in M. smegmatis, and in vitro and in vivo...
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