Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.

Abstract excerpt

TP53 missense mutations produce a mutant p53 protein that cannot activate the p53 tumor suppressive transcriptional response, which is the primary selective pressure for TP53 mutation. Specific codons of TP53, termed hotspot mutants, are mutated at elevated frequency. Hotspot forms of mutant p53 possess oncogenic properties in addition to being deficient in tumor suppression. Such p53 mutants accumulate to high...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Neoplastic
• Share to Mutation
• Share to Mutation, Missense