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Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT).

Cell death & disease - 9 Feb 2023

Falcinelli Marta, Dell'Omo Giulia, Grassi Elena, Mariella Elisa, Leto Simonetta Maria, Scardellato Sharon, Lorenzato Annalisa, Arena Sabrina, Bertotti Andrea, Trusolino Livio, Bardelli Alberto, d'Adda di Fagagna Fabrizio

Abstract excerpt

Telomere maintenance is necessary to maintain cancer cell unlimited viability. However, the mechanisms maintaining telomere length in colorectal cancer (CRC) have not been extensively investigated. Telomere maintenance mechanisms (TMM) include the re-expression of telomerase or alternative lengthening of telomeres (ALT). ALT is genetically associated with somatic alterations in alpha-thalassemia/mental...

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PMID: 36759506
DOI: 10.1038/s41419-023-05640-3
PMCID: PMC9911751

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