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PRL3 induces polyploid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse

29 Jul 2021

Abstract excerpt

Abstract PRL3, a unique oncotarget, is specifically overexpressed in 80.6% of cancers. In 2003, we reported that PRL3 promotes cell migration, invasion, and metastasis. Herein, firstly, we show that PRL3 induces Polyploid Giant Cancer Cells (PGCCs) formation. PGCCs constitute stem cell-like pools to facilitate cell survival, chemo-resistance, and tumor relapse. The correlations between PRL3 overexpression and...

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PMID: 34326464
DOI: 10.1038/s42003-021-02449-8

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