AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry.

doi:10.1007/s00401-013-1187-5

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Article

AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry.

Acta neuropathologica - 1 Nov 2013

Sahm Felix, Bissel Juliane, Koelsche Christian, Schweizer Leonille, Capper David, Reuss David, Böhmer Katja, Lass Ulrike, Göck Tanja, Kalis Katrin, Meyer Jochen, Habel Antje, Brehmer Stefanie, Mittelbronn Michel, Jones David T W, Schittenhelm Jens, Urbschat Steffi, Ketter Ralf, Heim Stephanie, Mawrin Christian, Hainfellner Johannes A, Berghoff Anna-Sophie, Preusser Matthias, Becker Albert, Herold-Mende Christel, Unterberg Andreas, Hartmann Christian, Kickingereder Philipp, Collins V Peter, Pfister Stefan M, von Deimling Andreas

Abstract excerpt

The activating E17K mutation in the AKT1 gene has been detected in several tumor entities. Currently several clinical studies with specific AKT1 inhibitors are under way. To determine whether AKT1 mutations are involved in human tumors of the nervous system, we examined a series of 1,437 tumors including 391 primary intracranial brain tumors and 1,046 tumors of the coverings of the central and peripheral nervous...

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Identifiers

PMID: 24096618
DOI: 10.1007/s00401-013-1187-5

Genes

AKT1
SFRP1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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