Article
Loss of SMARCB1/INI1 Immunoexpression in Chordoid Meningiomas.
Neurology India - 1 Jan 2000
Malgulwar Prit B, Kakkar Aanchal, Sharma Mehar C, Ghosh Ranajoy, Pathak Pankaj, Sarkar Chitra, Suri Vaishali, Singh Manmohan, Kale Shashank S, Faruq Mohammed
Abstract excerpt
BACKGROUND: Chordoid meningiomas have an aggressive clinical course characterized by frequent recurrences. Recent whole-genome sequencing studies demonstrated Chr22 loss in chordoid meningiomas not accounted for by NF2 mutations. SMARCB1/INI1 is a candidate gene on Chr22, which has not been analyzed extensively in meningiomas. AKT1 mutation has been recently identified to be a driver of meningiomagenesis....
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