Article
KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment.
Acta neuropathologica communications - 3 Apr 2020
von Spreckelsen Niklas, Waldt Natalie, Poetschke Rebecca, Kesseler Christoph, Dohmen Hildegard, Jiao Hui-Ke, Nemeth Attila, Schob Stefan, Scherlach Cordula, Sandalcioglu Ibrahim Erol, Deckert Martina, Angenstein Frank, Krischek Boris, Stavrinou Pantelis, Timmer Marco, Remke Marc, Kirches Elmar, Goldbrunner Roland, Chiocca E Antonio, Huettelmaier Stefan, Acker Till, Mawrin Christian
Abstract excerpt
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base...
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