Stringent Response Governs the Virulence and Oxidative Stress Resistance of Francisella tularensis

Abstract excerpt

Francisella tularensis is a Gram-negative bacterium responsible for causing tularemia in the northern hemisphere. F. tularensis has long been developed as a biological weapon due to its ability to cause severe illness upon inhalation of as few as ten organisms and based on its potential to be used as a bioterror agent is now classified as a Tier 1 Category A select agent by the CDC. The stringent response facilit...

Topics

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• Biofilms
• Gram-Negative Bacterial Infections
• Guanosine Tetraphosphate
• Macrophages
• Mice, Inbred BALB C
• Stress, Physiological
• Transcription Factor RelA
• Virulence

Identifiers and source

Literature Corpus work

02eccd93-01dd-50e6-9d9d-ca0b31965d1a

DOI

10.1101/653790