Article
LPS remodeling is an evolved survival strategy for bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012
Li Yanyan, Powell Daniel A, Shaffer Scott A, Rasko David A, Pelletier Mark R, Leszyk John D, Scott Alison J, Masoudi Ali, Goodlett David R, Wang Xiaoyuan, Raetz Christian R H, Ernst Robert K
Abstract excerpt
Maintenance of membrane function is essential and regulated at the genomic, transcriptional, and translational levels. Bacterial pathogens have a variety of mechanisms to adapt their membrane in response to transmission between environment, vector, and human host. Using a well-characterized model of lipid A diversification (Francisella), we demonstrate temperature-regulated membrane remodeling directed by...
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