Article
A Francisella mutant in lipid A carbohydrate modification elicits protective immunity.
PLoS pathogens - 8 Feb 2008
Kanistanon Duangjit, Hajjar Adeline M, Pelletier Mark R, Gallagher Larry A, Kalhorn Thomas, Shaffer Scott A, Goodlett David R, Rohmer Laurence, Brittnacher Mitchell J, Skerrett Shawn J, Ernst Robert K
Abstract excerpt
Francisella tularensis (Ft) is a highly infectious gram-negative bacterium and the causative agent of the human disease tularemia. Ft is designated a class A select agent by the Centers for Disease Control and Prevention. Human clinical isolates of Ft produce lipid A of similar structure to Ft subspecies novicida (Fn), a pathogen of mice. We identified three enzymes required for Fn lipid A carbohydrate...
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