Unique Francisella Phosphatidylethanolamine Acts as a Potent Anti-Inflammatory Lipid.

Abstract excerpt

Virulent Francisella tularensis subsp. tularensis (Ftt) is a dynamic, intracellular, bacterial pathogen. Its ability to evade and rapidly suppress host inflammatory responses is considered a key element for its profound virulence. We previously established that Ftt lipids play a role in inhibiting inflammation, but we did not determine the lipid species mediating this process. Here, we show that a unique,...

Topics

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• Immune Evasion
• Anti-Inflammatory Agents
• Dendritic Cells
• Francisella tularensis
• Macrophages