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Article

Indoleamine-2,3-dioxygenase(IDO)2 polymorphisms are not associated with multiple sclerosis in Italians.

Journal of the neurological sciences - 15 Jun 2017

Agliardi Cristina, Guerini Franca Rosa, Zanzottera Milena, Rovaris Marco, Caputo Domenico, Clerici Mario

Abstract excerpt

Indoleamine 2,3 dioxygenase (IDO)1 and IDO2 are enzymes playing a pivotal role in the metabolism of tryptophan and in immune modulation. IDO2, in particular, was recently suggested to drive B cell-mediated autoimmune diseases. Two functional polymorphisms within the IDO2 gene are described that result in the production of enzymes with suppressed activity; we analyzed these polymorphisms in a cohort of Italian...

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Source

Identifiers

PMID: 28477703
DOI: 10.1016/j.jns.2017.03.048

Genes

IDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Indoleamine-2,3-dioxygenase(IDO)2 polymorphisms are not associated with multiple sclerosis in Italians.PMID 28477703Read ↗

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