Article
LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis.
BMC neurology - 10 Apr 2013
García-Martín Elena, Lorenzo-Betancor Oswaldo, Martínez Carmen, Pastor Pau, Benito-León Julián, Millán-Pascual Jorge, Calleja Patricia, Díaz-Sánchez María, Pisa Diana, Turpín-Fenoll Laura, Alonso-Navarro Hortensia, Ayuso-Peralta Lucía, Torrecillas Dolores, Lorenzo Elena, Plaza-Nieto José Francisco, Agúndez José A G, Jiménez-Jiménez Félix Javier
Abstract excerpt
BACKGROUND: Some recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two common SNPs in the LINGO1 gene which have been associated to other neurological conditions, in patients with MS and in healthy subjects. These SNPs are linked to several SNPs within the LINGO1 gene,...
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