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Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis.

Human immunology - 1 Feb 2013

Tardito Samuele, Negrini Simone, Conteduca Giuseppina, Ferrera Francesca, Parodi Alessia, Battaglia Florinda, Kalli Francesca, Fenoglio Daniela, Cutolo Maurizio, Filaci Gilberto

Abstract excerpt

Systemic sclerosis (SSc) is characterized by tissue fibrosis, vasculopathy and autoimmunity. Indoleamine 2,3 dioxygenase (IDO) plays a pivotal role in immunological tolerance modulating regulatory T cell (Treg) generation and function. Single nucleotide polymorphisms (SNPs) of IDO gene could impact on Treg function and predispose to autoimmunity. Here, the existence of an association between specific IDO SNPs and...

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Identifiers

PMID: 23200754
DOI: 10.1016/j.humimm.2012.11.008

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