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Article

Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.

Scientific reports - 12 Feb 2016

Agúndez José A G, García-Martín Elena, Martínez Carmen, Benito-León Julián, Millán-Pascual Jorge, Díaz-Sánchez María, Calleja Patricia, Pisa Diana, Turpín-Fenoll Laura, Alonso-Navarro Hortensia, Pastor Pau, Ortega-Cubero Sara, Ayuso-Peralta Lucía, Torrecillas Dolores, García-Albea Esteban, Plaza-Nieto José Francisco, Jiménez-Jiménez Félix Javier

Abstract excerpt

Several neurochemical, neuropathological, and experimental data suggest a possible role of oxidative stress in the ethiopathogenesis of multiple sclerosis(MS). Heme-oxygenases(HMOX) are an important defensive mechanism against oxidative stress, and HMOX1 is overexpressed in the brain and spinal cord of MS patients and in experimental autoimmune encephalomyelitis(EAE). We analyzed whether common polymorphisms...

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Identifiers

PMID: 26868429
DOI: 10.1038/srep20830
PMCID: PMC4751624

Genes

HMOX2
HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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