Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.

doi:10.1016/j.arcmed.2016.11.018

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.

Archives of medical research - 1 Nov 2016

Jiménez-Morales Silvia, Ramírez-Florencio Mireya, Mejía-Aranguré Juan Manuel, Núñez-Enríquez Juan Carlos, Bekker-Mendez Carolina, Torres-Escalante José Luis, Flores-Lujano Janet, Jiménez-Hernández Elva, Del Carmen Rodríguez-Zepeda María, Leal Yelda A, González-Montalvo Pablo Miguel, Pantoja-Guillen Francisco, Peñaloza-Gonzalez José Gabriel, Gutiérrez-Juárez Erick Israel, Núñez-Villegas Nora Nancy, Pérez-Saldivar Maria Luisa, Guerra-Castillo Francisco Xavier, Flores-Villegas Luz Victoria, Ramos-Cervantes María Teresa, Fragoso José Manuel, García-Escalante María Guadalupe, Del Carmen Pinto-Escalante Doris, Ramírez-Bello Julián, Hidalgo-Miranda Alfredo

Abstract excerpt

BACKGROUND AND AIMS: It has been demonstrated that heterozygote and homozygote thiopurine S-methyltransferase (TPMT) mutant allele carriers are at high risk to develop severe and potentially fatal hematopoietic toxicity after treatment with standard doses of 6-mercaptopurine (6-MP) and methotrexate (MX). Those drugs are the backbone of acute lymphoblastic leukemia (ALL) and several autoimmune disease treatments....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antimetabolites, Antineoplastic

Share to Heterozygote

Share to Homozygote

Share to Mercaptopurine

Share to Methotrexate

Share to Methyltransferases

Share to Mexico

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 28476189
DOI: 10.1016/j.arcmed.2016.11.018

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.PMID 28476189Read ↗

Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.Semantic proximity Read ↗

TPMT genetic variations in populations of the Russian Federation.Semantic proximity Read ↗

The low frequency of defective TPMT alleles in Turkish population: a study on pediatric patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients.Semantic proximity Read ↗

Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.Semantic proximity Read ↗

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia.Semantic proximity Read ↗

No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.Semantic proximity Read ↗

Development of a rapid clinical TPMT genotyping assay.Semantic proximity Read ↗

Clinical pharmacogenomics of thiopurine S-methyltransferase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.