Article
Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: the Polish multicenter analysis.
Pediatric blood & cancer - 1 Oct 2011
Peregud-Pogorzelski Jarosław, Tetera-Rudnicka Edyta, Kurzawski Mateusz, Brodkiewicz Andrzej, Adrianowska Natalia, Mlynarski Wojciech, Januszkiewicz Danuta, Drozdzik Marek
Abstract excerpt
BACKGROUND: 6-Mercaptopurine (6-MP) is used for the treatment of pediatric acute lymphoblastic leukemia (ALL). Mutations in the TPMT gene may influence the efficacy and safety of 6-MP treatment. This multicenter study investigated the association between TPMT genotype, 6-MP dose adjustments, and the incidence of adverse effects in patients. PROCEDURE: A total of 203 ALL children were genotyped using...
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