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Article

Development of a rapid clinical TPMT genotyping assay.

Clinical biochemistry - 1 Oct 2014

Burchard Paul R, Abou Tayoun Ahmad N, Lefferts Joel A, Lewis Lionel D, Tsongalis Gregory J, Cervinski Mark A

Abstract excerpt

OBJECTIVES: Thiopurine compounds are commonly used in the treatment of childhood acute lymphoblastic leukemia, and as immunosuppressants following organ transplantation or for treatment of various autoimmune disorders. Thiopurine S-methyltransferase (TPMT) is required for detoxification, through S-methylation, of 6-thioguanine nucleotides (TGNs), a byproduct of thiopurine metabolism. Single nucleotide...

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Share to Genotype
Share to Genotyping Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

Share to Polymorphism, Single Nucleotide

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Purine-Pyrimidine Metabolism, Inborn Errors

Share to Thioguanine

Source

Identifiers

PMID: 25093923
DOI: 10.1016/j.clinbiochem.2014.07.088

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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