Article
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Cancer chemotherapy and pharmacology - 1 Aug 2021
Nielsen Stine Nygaard, Toksvang Linea Natalie, Grell Kathrine, Nersting Jacob, Abrahamsson Jonas, Lund Bendik, Kanerva Jukka, Jónsson Ólafur Gísli, Vaitkeviciene Goda, Pruunsild Kaie, Appell Malin Lindqvist, Hjalgrim Lisa Lyngsie, Schmiegelow Kjeld
Abstract excerpt
PURPOSE: 6-mercaptopurine(6MP)/methotrexate maintenance therapy is essential to reduce relapse of childhood acute lymphoblastic leukemia (ALL). Common germline variants in TPMT cause low activity of thiopurine methyltransferase (TPMT) and higher 6MP metabolite (TGN) levels. Higher levels of TGNs incorporated into DNA (DNA-TG) and low TPMT activity have previously been associated with a lower relapse risk. We...
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