Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population.

doi:10.1002/cpt.2716

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Implementation of NUDT15 Genotyping to Prevent Azathioprine-Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population.

Clinical pharmacology and therapeutics - 1 Nov 2022

Wang Chuang-Wei, Chi Min-Hui, Tsai Tsen-Fang, Yu Kuang-Hui, Kao Hsiao-Wen, Chen Hsiang-Cheng, Chen Chun-Bing, Lu Chun-Wei, Chen Wei-Ti, Chang Ya-Ching, Chang Chih-Jung, Chang Yun-Ting, Jan Wu Yeong-Jian, Chang Chee-Jen, Huang Yu Huei, Ng Chau-Yee, Huang Po-Wei, Lin Yu-Jr, Hui Rosaline Chung-Yee, Chung Wen-Hung

Abstract excerpt

Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia. Recent studies have identified genetic NUDT15 variants strongly associated with AZA-induced leukopenia in Asian patients. This study aimed to investigate the strength of above genetic association and evaluate the usefulness of prospective...

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PMID: 35869597
DOI: 10.1002/cpt.2716
PMCID: PMC9804440

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