Article
Transgenic mice expressing the T cell antigen receptor specific for an immunodominant epitope of a major allergen of house dust mite develop an asthmatic phenotype on exposure of the airways to allergen.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2005
Jarman E R, Tan K A L, Lamb J R
Abstract excerpt
BACKGROUND: Current studies on mechanisms underlying allergen-induced pulmonary inflammation and asthma are hampered by the lack of appropriate physiological in vivo models that reflect the natural route of allergen exposure and sensitization. OBJECTIVE: To generate and phenotype a transgenic mou...
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