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Article

Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure.

Nature communications - 15 Jul 2022

Vicente Anna Luiza Silva Almeida, Novoloaca Alexei, Cahais Vincent, Awada Zainab, Cuenin Cyrille, Spitz Natália, Carvalho André Lopes, Evangelista Adriane Feijó, Crovador Camila Souza, Reis Rui Manuel, Herceg Zdenko, de Lima Vazquez Vinicius, Ghantous Akram

Abstract excerpt

Ultraviolet radiation (UV) is causally linked to cutaneous melanoma, yet the underlying epigenetic mechanisms, known as molecular sensors of exposure, have not been characterized in clinical biospecimens. Here, we integrate clinical, epigenome (DNA methylome), genome and transcriptome profiling of 112 cutaneous melanoma from two multi-ethnic cohorts. We identify UV-related alterations in regulatory regions and...

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Cutaneous Melanoma Detection and Management
Epigenetics and DNA Methylation
Melanoma
Melanoma, Cutaneous Malignant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ultraviolet Rays

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PMID: 35840550
DOI: 10.1038/s41467-022-31488-w
PMCID: PMC9287446

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